Sandbox Reserved 1326
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | Protein binding:Selectively binds to other protein complexes non-covalently. Angiogenin promotes angiogenesis which is a stimulator of new blood vessels along with rRNA. RNH1 works to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 . | + | Protein binding:Selectively binds to other protein complexes non-covalently. Angiogenin promotes angiogenesis which is a stimulator of new blood vessels along with rRNA. RNH1 works to inhibit an endonuclease that cleaves phosphodiester bonds, RNASE1, and RNASE2 . The overall function of the complex is to inhibit angiogenin. RNase inhibitor neutralizes the angiogenic, ribonucleolytic, and phospholipase C-stimulating activites of angiogenin. |
== Disease == | == Disease == | ||
| - | <scene name='77/777646/Angiogenin/1'>Angiogenin</scene> has a role in cancers and tumor growth. A mutation in 1a4y which results in increased activity of Ang could lead to tumor growth. Angiogenin stimulates rRNA transcription when in cancer cells as it binds to ribosomal DNA. Ang has also been theorized as a protector of the central nervous system and thus under-production of 1a4y may result in limited Ang and thus neurodegenerative diseases. | + | <scene name='77/777646/Angiogenin/1'>Angiogenin</scene> has a role in cancers and tumor growth. A mutation in 1a4y which results in increased activity of Ang could lead to tumor growth. Angiogenin stimulates rRNA transcription when in cancer cells as it binds to ribosomal DNA, specifically research has shown that the highest upregulated gene in Akt-driven prostate intraepithelial neoplasia (PIN) in mice is Ang. Ang has also been theorized as a protector of the central nervous system and thus under-production of 1a4y may result in limited Ang and thus neurodegenerative diseases. |
== Relevance == | == Relevance == | ||
| - | Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders. Pharmaceutical products could utilize target angiogenin, especially in cases of prostate cancer which it has been found to play a major role. The neutrilization or diminishing of angiogenin in these cases could limit tumor growth and the effectiveness of cancer cells. | + | Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders. Pharmaceutical products could utilize target angiogenin, especially in cases of prostate cancer which it has been found to play a major role. The neutrilization or diminishing of lone angiogenin in these cases could limit tumor growth and the effectiveness of cancer cells. In addition pharmaceuticals could spur the complexing of Angiogenin and Ribonuclease Inhibitor 1. |
== Structural highlights == | == Structural highlights == | ||
<scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel <scene name='77/777646/Beta-strands/1'>beta-strands</scene> and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. The beta-strands hydrogen bond (usually 3) to form beta sheets which make up the backbone of the protein. Surrounding the backbone are alpha helices. Ribonuclease inhibitor is encoded by the gene RNH1. | <scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel <scene name='77/777646/Beta-strands/1'>beta-strands</scene> and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. The beta-strands hydrogen bond (usually 3) to form beta sheets which make up the backbone of the protein. Surrounding the backbone are alpha helices. Ribonuclease inhibitor is encoded by the gene RNH1. | ||
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<ref>DOI 10.1093/emboj/16.17.5162</ref> | <ref>DOI 10.1093/emboj/16.17.5162</ref> | ||
<ref>https://www.nature.com/articles/374183a0</ref> | <ref>https://www.nature.com/articles/374183a0</ref> | ||
| + | <ref>https://www.sciencedirect.com/science/article/pii/S0079660308602159</ref> | ||
Revision as of 20:42, 27 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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A Ribonuclease Inhibitor-Angiogenin Complex(1a4y)
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