5qfq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000491a== | |
| - | + | <StructureSection load='5qfq' size='340' side='right' caption='[[5qfq]], [[Resolution|resolution]] 1.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qfq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QFQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JK7:N-[(1S,2S,3S,4R)-3-hydroxy-1,2,3,4-tetrahydro-1,4-epoxynaphthalen-2-yl]cyclobutanecarboxamide'>JK7</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qfq OCA], [http://pdbe.org/5qfq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qfq RCSB], [http://www.ebi.ac.uk/pdbsum/5qfq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qfq ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Protein-tyrosine-phosphatase]] | ||
| + | [[Category: Biel, J T]] | ||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
| - | [[Category: | + | [[Category: Delft, F von]] |
| - | [[Category: | + | [[Category: Fraser, J S]] |
| - | [[Category: Hill, Z | + | [[Category: Hill, Z B]] |
| - | + | ||
[[Category: Kang, E]] | [[Category: Kang, E]] | ||
| - | [[Category: | + | [[Category: Keedy, D A]] |
| + | [[Category: Rettenmaier, T J]] | ||
| + | [[Category: Wells, J A]] | ||
| + | [[Category: Allostery]] | ||
| + | [[Category: Enzyme]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Multiconformer]] | ||
| + | [[Category: Pandda]] | ||
| + | [[Category: Protein tyrosine phosphatase]] | ||
| + | [[Category: Protein tyrosine phosphatase 1b]] | ||
| + | [[Category: Ptp]] | ||
| + | [[Category: Ptp1b]] | ||
| + | [[Category: Sgc - diamond i04-1 fragment screening]] | ||
Revision as of 07:55, 10 October 2018
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000491a
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Categories: Protein-tyrosine-phosphatase | Biel, J T | Brandao-Neto, J | Delft, F von | Fraser, J S | Hill, Z B | Kang, E | Keedy, D A | Rettenmaier, T J | Wells, J A | Allostery | Enzyme | Hydrolase | Multiconformer | Pandda | Protein tyrosine phosphatase | Protein tyrosine phosphatase 1b | Ptp | Ptp1b | Sgc - diamond i04-1 fragment screening
