6bed
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of VACV D13 in complex with Rifampicin== | |
| - | + | <StructureSection load='6bed' size='340' side='right' caption='[[6bed]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bed]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BED FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=RFP:RIFAMPICIN'>RFP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sam|3sam]], [[3saq|3saq]], [[6beb|6beb]], [[6bec|6bec]], [[6bee|6bee]], [[6bef|6bef]], [[6beg|6beg]], [[6beh|6beh]], [[6bei|6bei]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bed OCA], [http://pdbe.org/6bed PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bed RCSB], [http://www.ebi.ac.uk/pdbsum/6bed PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bed ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/D13_VACCW D13_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Accurso, C]] | ||
| + | [[Category: Coulibaly, F]] | ||
| + | [[Category: Garriga, D]] | ||
| + | [[Category: Assembly]] | ||
| + | [[Category: Immature virion]] | ||
| + | [[Category: Poxvirus]] | ||
| + | [[Category: Rifampicin resistance]] | ||
| + | [[Category: Scaffolding protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 07:34, 18 July 2018
Crystal structure of VACV D13 in complex with Rifampicin
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