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6cgw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR structure of JzTx-V, a Nav 1.7 inhibitory peptide== | |
| - | + | <StructureSection load='6cgw' size='340' side='right' caption='[[6cgw]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cgw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CGW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cgw OCA], [http://pdbe.org/6cgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cgw RCSB], [http://www.ebi.ac.uk/pdbsum/6cgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cgw ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/JZTX5_CHIGU JZTX5_CHIGU]] Inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels (Nav) in rat dorsal root ganglion neurons. Highly inhibits Kv4.2/KCND2 and Kv4.3/KCND3 potassium channels and weakly inhibits Kv2.1/KCNB1 potassium channels. The toxin shifts the activation curves to more depolarized potentials. Also binds to phospholipid membranes.<ref>PMID:17150181</ref> <ref>PMID:17157888</ref> <ref>PMID:18581053</ref> <ref>PMID:20571743</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Andrews, K]] | ||
| + | [[Category: Jordan, J B]] | ||
| + | [[Category: Fractionated tarantula venom]] | ||
| + | [[Category: Nav 1 7 inhibitor]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 08:09, 2 May 2018
Solution NMR structure of JzTx-V, a Nav 1.7 inhibitory peptide
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