6ft3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand== | |
| - | + | <StructureSection load='6ft3' size='340' side='right' caption='[[6ft3]], [[Resolution|resolution]] 1.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ft3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FT3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E5T:3-[(~{R})-cyclopropyl(oxidanyl)methyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)phenol'>E5T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ft3 OCA], [http://pdbe.org/6ft3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ft3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ft3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Conway, S J]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Filippakopoulos, P]] | [[Category: Filippakopoulos, P]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| - | [[Category: | + | [[Category: Picaud, S]] |
| + | [[Category: Pike, A C.W]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Isoxazole]] | ||
| + | [[Category: Ligand]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 05:52, 18 April 2018
Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
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