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2bzu

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Revision as of 19:46, 11 December 2019

Human Adenovirus Serotype 41 Fiber Head

Structural highlights

2bzu is a 1 chain structure with sequence from Ade41. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2bzv
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SPIK2_ADE41] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.

Crystal structure of enteric adenovirus serotype 41 short fiber head.,Seiradake E, Cusack S J Virol. 2005 Nov;79(22):14088-94. PMID:16254343^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Seiradake E, Cusack S. Crystal structure of enteric adenovirus serotype 41 short fiber head. J Virol. 2005 Nov;79(22):14088-94. PMID:16254343 doi:79/22/14088

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bzu"

@@ Line 1: / Line 1: @@
 ==Human Adenovirus Serotype 41 Fiber Head==
-<StructureSection load='2bzu' size='340' side='right' caption='[[2bzu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+<StructureSection load='2bzu' size='340' side='right'caption='[[2bzu]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2bzu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade41 Ade41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZU FirstGlance]. <br>
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Ade41]]
+[[Category: Large Structures]]
 [[Category: Cusack, S]]
 [[Category: Seiradake, E]]

2bzu

From Proteopedia

Revision as of 19:46, 11 December 2019

Human Adenovirus Serotype 41 Fiber Head

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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