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4rp5

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==Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21)==
==Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21)==
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<StructureSection load='4rp5' size='340' side='right' caption='[[4rp5]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='4rp5' size='340' side='right'caption='[[4rp5]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RP5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rp5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RP5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CG1725, Discs Large 1, dlg1, l(1)dlg1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rp5 OCA], [https://pdbe.org/4rp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rp5 RCSB], [https://www.ebi.ac.uk/pdbsum/4rp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rp5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rp5 OCA], [http://pdbe.org/4rp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/4rp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rp5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DLG1_DROME DLG1_DROME]] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.<ref>PMID:10884224</ref> <ref>PMID:12657668</ref> <ref>PMID:1651169</ref>
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[[https://www.uniprot.org/uniprot/DLG1_DROME DLG1_DROME]] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.<ref>PMID:10884224</ref> <ref>PMID:12657668</ref> <ref>PMID:1651169</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Ghosh, A]]
[[Category: Ghosh, A]]

Revision as of 05:08, 25 August 2022

Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21)

PDB ID 4rp5

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