2f3y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2f3y.gif|left|200px]]
[[Image:2f3y.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2f3y |SIZE=350|CAPTION= <scene name='initialview01'>2f3y</scene>, resolution 1.450&Aring;
+
The line below this paragraph, containing "STRUCTURE_2f3y", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= calm1, calm2, calm3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2f3y| PDB=2f3y | SCENE= }}
-
|RELATEDENTRY=[[1cdl|1CDL]], [[1cdm|1CDM]], [[1prw|1PRW]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3y OCA], [http://www.ebi.ac.uk/pdbsum/2f3y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f3y RCSB]</span>
+
-
}}
+
'''Calmodulin/IQ domain complex'''
'''Calmodulin/IQ domain complex'''
Line 27: Line 24:
[[Category: Fallon, J L.]]
[[Category: Fallon, J L.]]
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
-
[[Category: calcium channnel]]
+
[[Category: Calcium channnel]]
-
[[Category: calmodulin]]
+
[[Category: Calmodulin]]
-
[[Category: calmodulin complex]]
+
[[Category: Calmodulin complex]]
-
[[Category: cav1 2]]
+
[[Category: Cav1 2]]
-
[[Category: iq domain]]
+
[[Category: Iq domain]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:06 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:34 2008''
+

Revision as of 00:26, 4 May 2008

Image:2f3y.gif

Template:STRUCTURE 2f3y

Calmodulin/IQ domain complex


Overview

Ca2+-dependent inactivation (CDI) and facilitation (CDF) of the Ca(v)1.2 Ca2+ channel require calmodulin binding to a putative IQ motif in the carboxy-terminal tail of the pore-forming subunit. We present the 1.45 A crystal structure of Ca2+-calmodulin bound to a 21 residue peptide corresponding to the IQ domain of Ca(v)1.2. This structure shows that parallel binding of calmodulin to the IQ domain is governed by hydrophobic interactions. Mutations of residues I1672 and Q1673 in the peptide to alanines, which abolish CDI but not CDF in the channel, do not greatly alter the structure. Both lobes of Ca2+-saturated CaM bind to the IQ peptide but isoleucine 1672, thought to form an intramolecular interaction that drives CDI, is buried. These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF.

About this Structure

2F3Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel., Fallon JL, Halling DB, Hamilton SL, Quiocho FA, Structure. 2005 Dec;13(12):1881-6. PMID:16338416 Page seeded by OCA on Sun May 4 03:26:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f3y"
Personal tools