2klr
From Proteopedia
(Difference between revisions)
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==Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers== | ==Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers== | ||
- | <StructureSection load='2klr' size='340' side='right' caption='[[2klr]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2klr' size='340' side='right'caption='[[2klr]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[2klr]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2klr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLR FirstGlance]. <br> |
- | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRYAB, CRYA2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRYAB, CRYA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klr OCA], [https://pdbe.org/2klr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klr RCSB], [https://www.ebi.ac.uk/pdbsum/2klr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Art:Focusing on Crystallin|Art:Focusing on Crystallin]] | *[[Art:Focusing on Crystallin|Art:Focusing on Crystallin]] | ||
+ | *[[Crystallin 3D structures|Crystallin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Bardiaux, B]] | [[Category: Bardiaux, B]] | ||
[[Category: Higman, V A]] | [[Category: Higman, V A]] |
Revision as of 07:28, 14 April 2021
Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers
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Categories: Human | Large Structures | Bardiaux, B | Higman, V A | Jehle, S | Klevit, R E | Kuehne, R | Markovic, S | Oschkinat, H | Rajagopal, P | Rossum, B van | Cataract | Chaperone | Desmin-related myopathy | Dimer | Disease mutation | Eye lens protein | Glycoprotein | Heterogeneity | Intermolecular interaction | Methylation | Oligomer | Oxidation | Phosphoprotein | Protein | Shsp | Small heat-shock protein