2f4w

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[[Image:2f4w.gif|left|200px]]
[[Image:2f4w.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2f4w |SIZE=350|CAPTION= <scene name='initialview01'>2f4w</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2f4w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= UBE2J2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2f4w| PDB=2f4w | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f4w OCA], [http://www.ebi.ac.uk/pdbsum/2f4w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f4w RCSB]</span>
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}}
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'''Human ubiquitin-conjugating enzyme E2 J2'''
'''Human ubiquitin-conjugating enzyme E2 J2'''
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Xue, S.]]
[[Category: Xue, S.]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: structural genomics consortium (sgc)]]
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[[Category: Ubl conjugation pathway]]
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[[Category: ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:27:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:56 2008''
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Revision as of 00:27, 4 May 2008

Image:2f4w.gif

Template:STRUCTURE 2f4w

Human ubiquitin-conjugating enzyme E2 J2


Overview

Degradation of proteins from the endoplasmic reticulum is fundamental to quality control within the secretory pathway, serves as a way of regulating levels of crucial proteins, and is utilized by viruses to enhance pathogenesis. In yeast two ubiquitin-conjugating enzymes (E2s), UBC6p and UBC7p are implicated in this process. We now report the characterization of murine homologs of these E2s. MmUBC6 is an integral membrane protein that is anchored via its hydrophobic C-terminal tail to the endoplasmic reticulum. MmUBC7, which is not an integral membrane protein, shows significant endoplasmic reticulum colocalization with MmUBC6. Overexpression of catalytically inactive MmUBC7 significantly delayed degradation from the endoplasmic reticulum of two T cell antigen receptor subunits, alpha and CD3-delta, and suggests a role for the ubiquitin conjugating system at the initiation of retrograde movement from the endoplasmic reticulum. These findings also implicate, for the first time, a specific E2 in degradation from the endoplasmic reticulum in mammalian cells.

About this Structure

2F4W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)., Tiwari S, Weissman AM, J Biol Chem. 2001 May 11;276(19):16193-200. Epub 2001 Feb 2. PMID:11278356 Page seeded by OCA on Sun May 4 03:27:48 2008

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