Adenosine kinase

(Difference between revisions)

Revision as of 12:34, 24 April 2018

Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

Updated on 24-April-2018

↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

@@ Line 11: / Line 11: @@
 == Structural highlights ==
-AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene>.  The <scene name='57/573962/Cv/3'>active site</scene> is formed along the edge of the β sheet in the large domain (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
+AdK consists of a <scene name='57/573962/Cv/4'>large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices</scene> (PDB entry [[1bx4]]).<ref>PMID:9843365</ref>
+*<scene name='57/573962/Cv/6'>1st adenosine binding site</scene>. Water molecules are shown as red spheres.
+*<scene name='57/573962/Cv/7'>Cl coordination site</scene>.
+*<scene name='57/573962/Cv/8'>Cl/Mg cluster coordination site</scene>.
+*<scene name='57/573962/Cv/11'>2nd adenosine binding site</scene>.
 </StructureSection>