2f8y

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[[Image:2f8y.gif|left|200px]]
[[Image:2f8y.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2f8y |SIZE=350|CAPTION= <scene name='initialview01'>2f8y</scene>, resolution 1.55&Aring;
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The line below this paragraph, containing "STRUCTURE_2f8y", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Notch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2f8y| PDB=2f8y | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8y OCA], [http://www.ebi.ac.uk/pdbsum/2f8y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f8y RCSB]</span>
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}}
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'''Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.'''
'''Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.'''
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[[Category: Nam, Y.]]
[[Category: Nam, Y.]]
[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
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[[Category: ankyrin repeat]]
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[[Category: Ankyrin repeat]]
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[[Category: notch]]
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[[Category: Notch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:36:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:30 2008''
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Revision as of 00:36, 4 May 2008

Image:2f8y.gif

Template:STRUCTURE 2f8y

Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.


Overview

Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.

About this Structure

2F8Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:16530044 Page seeded by OCA on Sun May 4 03:36:15 2008

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