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2f9u
From Proteopedia
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[[Image:2f9u.gif|left|200px]] | [[Image:2f9u.gif|left|200px]] | ||
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'''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane''' | '''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane''' | ||
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[[Category: Venkatraman, S.]] | [[Category: Venkatraman, S.]] | ||
[[Category: Wu, W.]] | [[Category: Wu, W.]] | ||
| - | [[Category: | + | [[Category: Hcv]] |
| - | [[Category: | + | [[Category: Hepatitis c protease]] |
| - | [[Category: | + | [[Category: Ketoamide inhibitor]] |
| - | [[Category: | + | [[Category: Ns3 protease]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:38:29 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:38, 4 May 2008
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
Overview
Prolonged hepatitis C infection is the leading cause for cirrhosis of the liver and hepatocellular carcinoma. The etiological agent HCV virus codes a single polyprotein of approximately 3000 amino acids that is processed with the help of a serine protease NS3A to produce structural and non-structural proteins required for viral replication. Inhibition of NS3 protease can potentially be used to develop drugs for treatment of HCV infections. Herein, we report the development of a series of novel NS3 serine protease inhibitors derived from 2-aza-bicyclo[2.2.1]-heptane carboxylic acid with potential therapeutic use for treatment of HCV infections.
About this Structure
2F9U is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid., Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:16413182 Page seeded by OCA on Sun May 4 03:38:29 2008
