2f9v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2f9v.jpg|left|200px]]
[[Image:2f9v.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2f9v |SIZE=350|CAPTION= <scene name='initialview01'>2f9v</scene>, resolution 2.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_2f9v", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BN6:(2S,8R,9S,15S)-15-CYCLOHEXYL-9,12-BIS(CYCLOPROPYLMETHYL)-8-HYDROXY-20-METHYL-4,7,11,14,17-PENTAOXO-2-PHENYL-18-OXA-3,6,10,12,13,16-HEXAAZAHENICOSAN-1-OIC+ACID'>BN6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= NS3 protease domain ( residues 1027-1207 of the polyprotein). ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2f9v| PDB=2f9v | SCENE= }}
-
|RELATEDENTRY=[[1a1r|1A1R]], [[1jxp|1JXP]], [[2a4g|2A4G]], [[2a4q|2A4Q]], [[2a4r|2A4R]], [[1n1l|1N1L]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9v OCA], [http://www.ebi.ac.uk/pdbsum/2f9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f9v RCSB]</span>
+
-
}}
+
'''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines'''
'''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines'''
Line 35: Line 32:
[[Category: Ruan, S.]]
[[Category: Ruan, S.]]
[[Category: Saksena, A.]]
[[Category: Saksena, A.]]
-
[[Category: hcv]]
+
[[Category: Hcv]]
-
[[Category: hepatitis c protease]]
+
[[Category: Hepatitis c protease]]
-
[[Category: ketoamide inhibitor]]
+
[[Category: Ketoamide inhibitor]]
-
[[Category: ns3 protease]]
+
[[Category: Ns3 protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:38:32 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:57 2008''
+

Revision as of 00:38, 4 May 2008

Image:2f9v.jpg

Template:STRUCTURE 2f9v

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines


Overview

Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay.

About this Structure

2F9V is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:16387495 Page seeded by OCA on Sun May 4 03:38:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f9v"
Personal tools