2fau
From Proteopedia
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'''Crystal structure of human vps26''' | '''Crystal structure of human vps26''' | ||
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[[Category: Rojas, R.]] | [[Category: Rojas, R.]] | ||
[[Category: Shi, H.]] | [[Category: Shi, H.]] | ||
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| - | [[Category: | + | [[Category: Retromer]] |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:40, 4 May 2008
Crystal structure of human vps26
Overview
The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.
About this Structure
2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284 Page seeded by OCA on Sun May 4 03:40:17 2008
