6fu5

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m (Protected "6fu5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6fu5 is ON HOLD
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==Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18==
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<StructureSection load='6fu5' size='340' side='right' caption='[[6fu5]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
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Authors: Pinkas, D.M., Bufton, J.C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fu5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU5 FirstGlance]. <br>
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Description: Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7N:~{N}-[5-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2-methoxy-phenyl]propane-1-sulfonamide'>E7N</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu5 OCA], [http://pdbe.org/6fu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu5 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu5 ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Burgess-Brown, N.A]]
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== Function ==
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[[Category: Von Delft, F]]
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[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>
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[[Category: Bullock, A.N]]
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== References ==
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[[Category: Bufton, J.C]]
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<references/>
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[[Category: Pinkas, D.M]]
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__TOC__
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[[Category: Edwards, A.M]]
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</StructureSection>
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Bufton, J C]]
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[[Category: Bullock, A N]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
[[Category: Kupinska, K]]
[[Category: Kupinska, K]]
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[[Category: Pinkas, D M]]
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[[Category: Ai domain]]
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[[Category: Cct domain]]
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[[Category: Peptide binding protein]]
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[[Category: Rfxv motif binding]]
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[[Category: Wnk2]]

Revision as of 05:39, 25 April 2018

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP18

6fu5, resolution 3.26Å

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