2fbe

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[[Image:2fbe.gif|left|200px]]
[[Image:2fbe.gif|left|200px]]
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{{Structure
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|PDB= 2fbe |SIZE=350|CAPTION= <scene name='initialview01'>2fbe</scene>, resolution 2.52&Aring;
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The line below this paragraph, containing "STRUCTURE_2fbe", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= gene 19q13.4.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2fbe| PDB=2fbe | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbe OCA], [http://www.ebi.ac.uk/pdbsum/2fbe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fbe RCSB]</span>
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'''Crystal Structure of the PRYSPRY-domain'''
'''Crystal Structure of the PRYSPRY-domain'''
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[[Category: Gruetter, M G.]]
[[Category: Gruetter, M G.]]
[[Category: Mittl, P R.]]
[[Category: Mittl, P R.]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: jellyroll beta-sandwich fold]]
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[[Category: Jellyroll beta-sandwich fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:41:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:00:27 2008''
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Revision as of 00:41, 4 May 2008

Image:2fbe.gif

Template:STRUCTURE 2fbe

Crystal Structure of the PRYSPRY-domain


Overview

We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.

About this Structure

2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311 Page seeded by OCA on Sun May 4 03:41:33 2008

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