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2iip
From Proteopedia
(Difference between revisions)
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==Human Nicotinamide N-methyltransferase== | ==Human Nicotinamide N-methyltransferase== | ||
| - | <StructureSection load='2iip' size='340' side='right' caption='[[2iip]], [[Resolution|resolution]] 2.05Å' scene=''> | + | <StructureSection load='2iip' size='340' side='right'caption='[[2iip]], [[Resolution|resolution]] 2.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2iip]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IIP FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NNMT ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NNMT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iip OCA], [https://pdbe.org/2iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iip RCSB], [https://www.ebi.ac.uk/pdbsum/2iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iip ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NNMT_HUMAN NNMT_HUMAN]] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Nicotinamide N-methyltransferase]] | [[Category: Nicotinamide N-methyltransferase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 11:16, 31 March 2021
Human Nicotinamide N-methyltransferase
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Categories: Human | Large Structures | Nicotinamide N-methyltransferase | Arrowsmith, C H | Avvakumov, G V | Bernstein, G | Bochkarev, A | Edwards, A M | Loppnau, P | Min, J | Plotnikov, A N | Structural genomic | Sundstrom, M | Tempel, W | Wasney, G | Weigelt, J | Wu, H | Zeng, H | Methyltransferase | Mutant | Mutation | Sgc | Surface mutagenesis | Transferase
