2fe4
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2fe4.gif|left|200px]] | [[Image:2fe4.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2fe4", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_2fe4| PDB=2fe4 | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''The crystal structure of human neuronal Rab6B in its inactive GDP-bound form''' | '''The crystal structure of human neuronal Rab6B in its inactive GDP-bound form''' | ||
| Line 28: | Line 25: | ||
[[Category: Kozielski, F.]] | [[Category: Kozielski, F.]] | ||
[[Category: Tcherniuk, F.]] | [[Category: Tcherniuk, F.]] | ||
| - | [[Category: | + | [[Category: Protein-nucleotide complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:47:18 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:47, 4 May 2008
The crystal structure of human neuronal Rab6B in its inactive GDP-bound form
Overview
The Rab small G-protein family plays important roles in eukaryotes as regulators of vesicle traffic. In Rab proteins, the hydrolysis of GTP to GDP is coupled with association with and dissociation from membranes. Conformational changes related to their different nucleotide states determine their effector specificity. The crystal structure of human neuronal Rab6B was solved in its 'inactive' (with bound MgGDP) and 'active' (MgGTPgammaS-bound) forms to 2.3 and 1.8 A, respectively. Both crystallized in space group P2(1)2(1)2(1), with similar unit-cell parameters, allowing the comparison of both structures without packing artifacts. Conformational changes between the inactive GDP and active GTP-like state are observed mainly in the switch I and switch II regions, confirming their role as a molecular switch. Compared with other Rab proteins, additional changes are observed in the Rab6 subfamily-specific RabSF3 region that might contribute to the specificity of Rab6 for its different effector proteins.
About this Structure
2FE4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of human neuronal Rab6B in the active and inactive form., Garcia-Saez I, Tcherniuk S, Kozielski F, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):725-33. Epub 2006, Jun 20. PMID:16790928 Page seeded by OCA on Sun May 4 03:47:18 2008
