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5cga

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==Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol==
==Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol==
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<StructureSection load='5cga' size='340' side='right' caption='[[5cga]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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<StructureSection load='5cga' size='340' side='right'caption='[[5cga]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cga]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cga]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KP6:2-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)ETHANOL'>KP6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KP6:2-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)ETHANOL'>KP6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiM, SAR2181 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cga OCA], [https://pdbe.org/5cga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cga RCSB], [https://www.ebi.ac.uk/pdbsum/5cga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cga ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.50 2.7.1.50] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cga OCA], [http://pdbe.org/5cga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cga RCSB], [http://www.ebi.ac.uk/pdbsum/5cga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cga ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THIM_STAAR THIM_STAAR]] Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
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[https://www.uniprot.org/uniprot/THIM_STAAR THIM_STAAR] Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staar]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
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[[Category: Betzel, C]]
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[[Category: Betzel C]]
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[[Category: Cang, H]]
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[[Category: Cang H]]
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[[Category: Drebes, J]]
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[[Category: Drebes J]]
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[[Category: Kuenz, M]]
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[[Category: Kuenz M]]
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[[Category: Windshuegel, B]]
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[[Category: Windshuegel B]]
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[[Category: Wrenger, C]]
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[[Category: Wrenger C]]
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[[Category: Bacterial thiamine biosynthesis]]
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[[Category: Hydroxyethylthiazole kinase]]
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[[Category: Substrate analog]]
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Revision as of 12:03, 14 June 2023

Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol

PDB ID 5cga

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