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5nsd

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Current revision (12:05, 22 November 2023) (edit) (undo)
 
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==Co-crystal structure of NAMPT dimer with KPT-9274==
==Co-crystal structure of NAMPT dimer with KPT-9274==
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<StructureSection load='5nsd' size='340' side='right' caption='[[5nsd]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='5nsd' size='340' side='right'caption='[[5nsd]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nsd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NSD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nsd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NSD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=96Q:(~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide'>96Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.046&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAMPT, PBEF, PBEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=96Q:(~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide'>96Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nsd OCA], [https://pdbe.org/5nsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nsd RCSB], [https://www.ebi.ac.uk/pdbsum/5nsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nsd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nsd OCA], [http://pdbe.org/5nsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nsd RCSB], [http://www.ebi.ac.uk/pdbsum/5nsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nsd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nsd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nsd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Baloglu, E]]
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[[Category: Baloglu E]]
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[[Category: Daelemans, D]]
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[[Category: Daelemans D]]
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[[Category: Dierckx, T]]
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[[Category: Dierckx T]]
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[[Category: Jacquemyn, M]]
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[[Category: Jacquemyn M]]
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[[Category: Kwanten, B]]
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[[Category: Kwanten B]]
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[[Category: Neggers, J E]]
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[[Category: Neggers JE]]
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[[Category: Noguchi, H]]
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[[Category: Noguchi H]]
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[[Category: Senapedis, W]]
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[[Category: Senapedis W]]
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[[Category: Vercruysse, T]]
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[[Category: Vercruysse T]]
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[[Category: Voet, A]]
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[[Category: Voet A]]
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[[Category: Crispr/ca]]
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[[Category: Drug target]]
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[[Category: Nampt]]
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[[Category: Transferase]]
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Current revision

Co-crystal structure of NAMPT dimer with KPT-9274

PDB ID 5nsd

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