2fh0
From Proteopedia
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'''NMR Ensemble of The Yeast Saccharomyces cerevisiae protein Ymr074cp core region''' | '''NMR Ensemble of The Yeast Saccharomyces cerevisiae protein Ymr074cp core region''' | ||
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[[Category: Wu, J H.]] | [[Category: Wu, J H.]] | ||
[[Category: Zhang, J H.]] | [[Category: Zhang, J H.]] | ||
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| - | [[Category: | + | [[Category: Ymr074cp]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:53:04 2008'' | |
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Revision as of 00:53, 4 May 2008
NMR Ensemble of The Yeast Saccharomyces cerevisiae protein Ymr074cp core region
Overview
A set of 424 nonmembrane proteins from Methanobacterium thermoautotrophicum were cloned, expressed and purified for structural studies. Of these, approximately 20% were found to be suitable candidates for X-ray crystallographic or NMR spectroscopic analysis without further optimization of conditions, providing an estimate of the number of the most accessible structural targets in the proteome. A retrospective analysis of the experimental behavior of these proteins suggested some simple relations between sequence and solubility, implying that data bases of protein properties will be useful in optimizing high throughput strategies. Of the first 10 structures determined, several provided clues to biochemical functions that were not detectable from sequence analysis, and in many cases these putative functions could be readily confirmed by biochemical methods. This demonstrates that structural proteomics is feasible and can play a central role in functional genomics.
About this Structure
2FH0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structural proteomics of an archaeon., Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, Kennedy MA, Davidson AR, Pai EF, Gerstein M, Edwards AM, Arrowsmith CH, Nat Struct Biol. 2000 Oct;7(10):903-9. PMID:11017201 Page seeded by OCA on Sun May 4 03:53:04 2008
