This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2fhy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fhy.gif|left|200px]]
[[Image:2fhy.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fhy |SIZE=350|CAPTION= <scene name='initialview01'>2fhy</scene>, resolution 2.95&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fhy", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A37:2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE'>A37</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fhy| PDB=2fhy | SCENE= }}
-
|RELATEDENTRY=[[2fie|2FIE]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fhy OCA], [http://www.ebi.ac.uk/pdbsum/2fhy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fhy RCSB]</span>
+
-
}}
+
'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
Line 27: Line 24:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Abad-Zapatero, C.]]
[[Category: Abad-Zapatero, C.]]
-
[[Category: allosteric inhibitors human fbpase]]
+
[[Category: Allosteric inhibitors human fbpase]]
-
[[Category: benzoxazole]]
+
[[Category: Benzoxazole]]
-
[[Category: intersubunit allosteric inhibition of human fpbase]]
+
[[Category: Intersubunit allosteric inhibition of human fpbase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:10 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:03:04 2008''
+

Revision as of 00:55, 4 May 2008

Image:2fhy.gif

Template:STRUCTURE 2fhy

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor


Overview

We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.

About this Structure

2FHY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:16442285 Page seeded by OCA on Sun May 4 03:55:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fhy"
Personal tools