Agglutinin

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== Structural highlights ==
== Structural highlights ==
Agglutinin binds polysaccharide composed of α- and β-mannose in its active site<ref>PMID:23480609</ref>.
Agglutinin binds polysaccharide composed of α- and β-mannose in its active site<ref>PMID:23480609</ref>.
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*<scene name='74/749490/Cv/2'>1st poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/6'>1st poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/3'>2nd poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/7'>2nd poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/4'>3rd poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/8'>3rd poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/5'>4th poly-mannose binding site</scene>.
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*<scene name='74/749490/Cv/9'>4th poly-mannose binding site</scene>.

Revision as of 13:52, 25 April 2018

Agglutinin complex with polysaccharide of α- and β-mannose, imidazole and Na+ ion (purple) (PDB code 4gk9)

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3D Structures of lactoferrin

Updated on 25-April-2018

References

  1. Dalla Pellegrina C, Perbellini O, Scupoli MT, Tomelleri C, Zanetti C, Zoccatelli G, Fusi M, Peruffo A, Rizzi C, Chignola R. Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):146-53. doi:, 10.1016/j.taap.2009.03.012. Epub 2009 Mar 28. PMID:19332085 doi:http://dx.doi.org/10.1016/j.taap.2009.03.012
  2. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013 Aug 15;122(7):1114-21. doi: 10.1182/blood-2013-02-474437. Epub 2013, Jun 11. PMID:23757733 doi:http://dx.doi.org/10.1182/blood-2013-02-474437
  3. Whitley MJ, Furey W, Kollipara S, Gronenborn AM. Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity. FEBS J. 2013 May;280(9):2056-67. doi: 10.1111/febs.12229. Epub 2013 Apr 2. PMID:23480609 doi:10.1111/febs.12229

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