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Aldose Reductase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1ads' size=' | + | <StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/ | + | AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> <scene name='43/436098/Cv/7'>Active site interactions</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 13:20, 29 April 2018
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3D Structures of Aldose Reductase
Updated on 29-April-2018
References
- ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
- ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098
