5zct
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of the poly-alpha-L-glutamate peptides synthetase RimK at 2.05 angstrom resolution.== |
| + | <StructureSection load='5zct' size='340' side='right' caption='[[5zct]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5zct]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZCT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zct OCA], [http://pdbe.org/5zct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zct RCSB], [http://www.ebi.ac.uk/pdbsum/5zct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zct ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RIMK_ECOLI RIMK_ECOLI]] Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial RimK is an enzyme that catalyzes the polyglutamylation of the C-terminus of ribosomal protein S6 and the synthesis of poly-alpha-L-glutamate peptides using L-glutamic acid. In the present study, the crystal structure of the Escherichia coli RimK protein complexed with the ATP analogue AMP-PNP was determined at 2.05 A resolution. Two different conformations of RimK, closed and open forms, were observed in the crystals. The structural polymorphism revealed in this study provided important information to understand the mechanism by which RimK catalyzes the synthesis of poly-alpha-L-glutamate peptides and the polyglutamylation of ribosomal protein S6. | ||
| - | + | Structural polymorphism of the Escherichia coli poly-alpha-L-glutamate synthetase RimK.,Arimura Y, Kono T, Kino K, Kurumizaka H Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):385-390. doi:, 10.1107/S2053230X18007689. Epub 2018 Jun 26. PMID:29969101<ref>PMID:29969101</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5zct" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arimura, Y]] | ||
| + | [[Category: Kino, K]] | ||
| + | [[Category: Kono, T]] | ||
| + | [[Category: Kurumizaka, H]] | ||
| + | [[Category: L-amino acid ligase]] | ||
| + | [[Category: Ligase]] | ||
Revision as of 07:11, 25 July 2018
The crystal structure of the poly-alpha-L-glutamate peptides synthetase RimK at 2.05 angstrom resolution.
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