2flb

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[[Image:2flb.gif|left|200px]]
[[Image:2flb.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2flb |SIZE=350|CAPTION= <scene name='initialview01'>2flb</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_2flb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=6NH:2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>6NH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2flb| PDB=2flb | SCENE= }}
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|RELATEDENTRY=[[1o5d|1o5d]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2flb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2flb OCA], [http://www.ebi.ac.uk/pdbsum/2flb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2flb RCSB]</span>
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}}
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'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Katz, B A.]]
[[Category: Katz, B A.]]
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[[Category: active site-directed]]
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[[Category: Active site-directed]]
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[[Category: pyrazole-based inhibitor]]
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[[Category: Pyrazole-based inhibitor]]
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[[Category: short hydrogen bond-mediated]]
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[[Category: Short hydrogen bond-mediated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:01:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:20 2008''
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Revision as of 01:01, 4 May 2008

Image:2flb.gif

Template:STRUCTURE 2flb

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor


Contents

Overview

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2FLB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703 Page seeded by OCA on Sun May 4 04:01:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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