6fxb

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m (Protected "6fxb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6fxb is ON HOLD
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==Bovine beta-lactoglobulin variant A at pH 4.0==
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<StructureSection load='6fxb' size='340' side='right' caption='[[6fxb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fxb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FXB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxb OCA], [http://pdbe.org/6fxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fxb RCSB], [http://www.ebi.ac.uk/pdbsum/6fxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxb ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The dimeric structure of bovine beta-lactoglobulin A (BLGA) at pH 4.0 was solved to 2.0 A resolution. Fitting the BLGA pH 4.0 structure to SAXS data at low ionic strength (goodness of fit R-factor = 3.6%) verified the dimeric state in solution. Analysis of the monomer-dimer equilibrium at varying pH and ionic strength by SAXS and scattering modeling showed that BLGA is dimeric at pH 3.0 and 4.0, shifting toward a monomer at pH 2.2, 2.6, and 7.0 yielding monomer/dimer ratios of 80/20%, 50/50%, and 25/75%, respectively. BLGA remained a dimer at pH 3.0 and 4.0 in 50-150 mM NaCl, whereas the electrostatic shielding raised the dimer content at pH 2.2, 2.6, and 7.0, i.e., below and above the pI. Overall, the findings provide new insights into the molecular characteristics of BLGA relevant for dairy product formulations and for various biotechnological and pharmaceutical applications.
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Authors: Khan, S., Ipsen, R., Almdal, K., Svensson, B., Harris, P.
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Revealing the Dimeric Crystal and Solution Structure of beta-Lactoglobulin at pH 4 and Its pH and Salt Dependent Monomer-Dimer Equilibrium.,Khan S, Ipsen R, Almdal K, Svensson B, Harris P Biomacromolecules. 2018 May 15. doi: 10.1021/acs.biomac.8b00471. PMID:29737841<ref>PMID:29737841</ref>
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Description: Bovine beta-lactoglobulin variant A at pH 4.0
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6fxb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
[[Category: Almdal, K]]
[[Category: Almdal, K]]
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[[Category: Harris, P]]
[[Category: Ipsen, R]]
[[Category: Ipsen, R]]
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[[Category: Svensson, B]]
 
[[Category: Khan, S]]
[[Category: Khan, S]]
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[[Category: Harris, P]]
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[[Category: Svensson, B]]
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[[Category: Allergen]]
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[[Category: Lactoglobulin]]
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[[Category: Milk protein]]

Revision as of 07:29, 23 May 2018

Bovine beta-lactoglobulin variant A at pH 4.0

6fxb, resolution 2.00Å

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