2fmd

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[[Image:2fmd.gif|left|200px]]
[[Image:2fmd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fmd |SIZE=350|CAPTION= <scene name='initialview01'>2fmd</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_2fmd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ASX:ASP/ASN+AMBIGUOUS'>ASX</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2fmd| PDB=2fmd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmd OCA], [http://www.ebi.ac.uk/pdbsum/2fmd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fmd RCSB]</span>
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}}
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'''Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin'''
'''Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin'''
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[[Category: Loris, R.]]
[[Category: Loris, R.]]
[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
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[[Category: beta sandwich]]
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[[Category: Beta sandwich]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: legume lectin]]
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[[Category: Legume lectin]]
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[[Category: protein-carbohydrate complex]]
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[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:04:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:52 2008''
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Revision as of 01:04, 4 May 2008

Image:2fmd.gif

Template:STRUCTURE 2fmd

Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin


Overview

The crystal structure of the seed lectin from the tropical legume Bowringia milbraedii was determined in complex with the disaccharide ligand Man(alpha1-2)Man. In solution, the protein exhibits a dynamic dimer-tetramer equilibrium, consistent with the concanavalin A-type tetramer observed in the crystal. Contacts between the tetramers are mediated almost exclusively through the carbohydrate ligand, resulting in a crystal lattice virtually identical to that of the concanavalin-A:Man(alpha1-2)Man complex, even though both proteins have less than 50% sequence identity. The disaccharide binds exclusively in a "downstream" binding mode, with the non-reducing mannose occupying the monosaccharide-binding site. The reducing mannose is bound in a predominantly polar subsite involving Tyr131, Gln218, and Tyr219.

About this Structure

2FMD is a Single protein structure of sequence from Bowringia mildbraedii. Full crystallographic information is available from OCA.

Reference

Structural basis of carbohydrate recognition by a Man(alpha1-2)Man-specific lectin from Bowringia milbraedii., Buts L, Garcia-Pino A, Wyns L, Loris R, Glycobiology. 2006 Jul;16(7):635-40. Epub 2006 Mar 27. PMID:16567368 Page seeded by OCA on Sun May 4 04:04:00 2008

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