User:Kyle Burton/Sandbox1

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Background & Significance

Sex Lethal Protein (i.e. Sxl) is a splicing repressor in the male developmental pathway of the common fruit fly, Drosophila melanogaster. Sxl regulates alternative splicing pathways to promote the expression of female sex-linked proteins. Its RNA splicing targets encode for the transformer (Tra) and the male-sex lethal (Msl-2) proteins. Tra is a splicing activator in the female developmental pathway, and Msl2 modulates X chromosome application in male fruit flies. The mechanism for how Sxl targets these pathways differs slightly. In both mechanisms, Sxl occupies the 3' splice site and prevents U2AF from binding. U2AF is a vital splicing factor observed in the male developmental pathway. In Msl-2 targeting, Sxl also blocks another regulatory splicing factor, TIA-1, and the U1 snRNP. Sxl also has the ability to control its own splicing pattern in order to conserve female expression. It does so by surrounding Exon 3 of its own RNA and creating a RNP complex to eliminate this exon. Upon this elimination, Sxl becomes active and female expression is maintained. The structural interactions with regards to the targeting of the 5' splice site and of its own mRNA transcript is much less understood than the competition of Sxl with U2AF at the 3' splice site. Media: https://www.youtube.com/watch?v=7usaaiggDgw

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.