5ov3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the RbBP5 beta-propeller domain== | |
| - | + | <StructureSection load='5ov3' size='340' side='right' caption='[[5ov3]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ov3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OV3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ov3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ov3 OCA], [http://pdbe.org/5ov3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ov3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ov3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ov3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gamblin, S J]] | ||
| + | [[Category: Mittal, A]] | ||
| + | [[Category: Wilson, J R]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Wd40 beta-propeller]] | ||
Revision as of 06:30, 28 March 2018
Structure of the RbBP5 beta-propeller domain
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