This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5ov3
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the RbBP5 beta-propeller domain== | |
| - | + | <StructureSection load='5ov3' size='340' side='right' caption='[[5ov3]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ov3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OV3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ov3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ov3 OCA], [http://pdbe.org/5ov3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ov3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ov3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ov3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gamblin, S J]] | ||
| + | [[Category: Mittal, A]] | ||
| + | [[Category: Wilson, J R]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Wd40 beta-propeller]] | ||
Revision as of 06:30, 28 March 2018
Structure of the RbBP5 beta-propeller domain
| |||||||||||
