2ful
From Proteopedia
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[[Image:2ful.gif|left|200px]] | [[Image:2ful.gif|left|200px]] | ||
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'''Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5''' | '''Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5''' | ||
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[[Category: Xu, H.]] | [[Category: Xu, H.]] | ||
[[Category: Xue, Y.]] | [[Category: Xue, Y.]] | ||
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Revision as of 01:19, 4 May 2008
Crystal Structure of the C-terminal Domain of S. cerevisiae eIF5
Overview
eIF5, a GTPase-activating protein (GAP) specific for eIF2, plays a critical role in pre-initiation complex assembly and correct AUG selection during eukaryotic translation initiation. eIF5 is involved in the formation of the multifactor complex (MFC), an important intermediate of the 43S pre-initiation complex. The C-terminal domain (CTD) of eIF5 functions as the structural core in the MFC assembly. Here we report the 1.5A crystal structure of eIF5-CTD, confirming that eIF5-CTD contains an atypical HEAT motif. In addition, analyzing the electrostatic potential and the distribution of conserved residues on the protein surface, we confirm and suggest some potential regions of interactions between eIF5-CTD and other eIFs. The structure of eIF5-CTD provides useful information in understanding the mechanism of the MFC assembly.
About this Structure
2FUL is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal domain of S.cerevisiae eIF5., Wei Z, Xue Y, Xu H, Gong W, J Mol Biol. 2006 May 26;359(1):1-9. Epub 2006 Mar 31. PMID:16616930 Page seeded by OCA on Sun May 4 04:19:40 2008
