2fw4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fw4.gif|left|200px]]
[[Image:2fw4.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fw4 |SIZE=350|CAPTION= <scene name='initialview01'>2fw4</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fw4", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fw4| PDB=2fw4 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fw4 OCA], [http://www.ebi.ac.uk/pdbsum/2fw4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fw4 RCSB]</span>
+
-
}}
+
'''Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.'''
'''Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.'''
Line 29: Line 26:
[[Category: Supuran, C T.]]
[[Category: Supuran, C T.]]
[[Category: Temperini, C.]]
[[Category: Temperini, C.]]
-
[[Category: activator]]
+
[[Category: Activator]]
-
[[Category: carbonic anhydrase i]]
+
[[Category: Carbonic anhydrase i]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:22:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:33 2008''
+

Revision as of 01:22, 4 May 2008

Image:2fw4.gif

Template:STRUCTURE 2fw4

Carbonic anhydrase activators. The first X-ray crystallographic study of an activator of isoform I, structure with L-histidine.


Overview

The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.

About this Structure

2FW4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I., Temperini C, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5152-6. Epub 2006 Jul 25. PMID:16870440 Page seeded by OCA on Sun May 4 04:22:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fw4"
Personal tools