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2fx0

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[[Image:2fx0.gif|left|200px]]
[[Image:2fx0.gif|left|200px]]
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{{Structure
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|PDB= 2fx0 |SIZE=350|CAPTION= <scene name='initialview01'>2fx0</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2fx0", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= hlyIIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 Bacillus cereus])
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{{STRUCTURE_2fx0| PDB=2fx0 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fx0 OCA], [http://www.ebi.ac.uk/pdbsum/2fx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fx0 RCSB]</span>
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'''Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator'''
'''Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator'''
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[[Category: Lebedev, A A.]]
[[Category: Lebedev, A A.]]
[[Category: Solonin, A S.]]
[[Category: Solonin, A S.]]
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[[Category: transcriptional regulator]]
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[[Category: Transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:24:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:48 2008''
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Revision as of 01:24, 4 May 2008

Image:2fx0.gif

Template:STRUCTURE 2fx0

Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator


Overview

Production of Bacillus cereus and Bacillus anthracis toxins is controlled by a number of transcriptional regulators. Here we report the crystal structure of B. cereus HlyIIR, a regulator of the gene encoding the pore-forming toxin hemolysin II. We show that HlyIIR forms a tight dimer with a fold and overall architecture similar to the TetR family of repressors. A remarkable feature of the structure is a large internal cavity with a volume of 550 A(3) suggesting that the activity of HlyIIR is modulated by binding of a ligand, which triggers the toxin production. Virtual ligand library screening shows that this pocket can accommodate compounds with molecular masses of up to 400-500 Da. Based on structural data and previous biochemical evidence, we propose a model for HlyIIR interaction with the DNA.

About this Structure

2FX0 is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus cereus HlyIIR, a transcriptional regulator of the gene for pore-forming toxin hemolysin II., Kovalevskiy OV, Lebedev AA, Surin AK, Solonin AS, Antson AA, J Mol Biol. 2007 Jan 19;365(3):825-34. Epub 2006 Oct 26. PMID:17097673 Page seeded by OCA on Sun May 4 04:24:19 2008

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