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2fxl

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[[Image:2fxl.gif|left|200px]]
[[Image:2fxl.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fxl |SIZE=350|CAPTION= <scene name='initialview01'>2fxl</scene>, resolution 1.76&Aring;
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The line below this paragraph, containing "STRUCTURE_2fxl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2AL:1-(2,5-DIOXO-2,5-DIHYDRO-1H-IMIDAZOL-4-YL)UREA'>2AL</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 Aspergillus flavus])
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-->
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|DOMAIN=
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{{STRUCTURE_2fxl| PDB=2fxl | SCENE= }}
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|RELATEDENTRY=[[1r4s|1R4S]], [[1r4u|1R4U]], [[1r51|1R51]], [[1r56|1R56]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxl OCA], [http://www.ebi.ac.uk/pdbsum/2fxl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fxl RCSB]</span>
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}}
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'''Urate oxidase from aspergillus flavus complexed with allantoin'''
'''Urate oxidase from aspergillus flavus complexed with allantoin'''
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[[Category: H, N Colloc.]]
[[Category: H, N Colloc.]]
[[Category: Prange, T.]]
[[Category: Prange, T.]]
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[[Category: allantoin]]
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[[Category: Allantoin]]
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[[Category: dimeric barrel]]
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[[Category: Dimeric barrel]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: tunnel-shaped protein]]
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[[Category: Tunnel-shaped protein]]
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[[Category: uric acid degradation]]
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[[Category: Uric acid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:09:00 2008''
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Revision as of 01:25, 4 May 2008

Image:2fxl.gif

Template:STRUCTURE 2fxl

Urate oxidase from aspergillus flavus complexed with allantoin


Overview

Urate oxidase from Aspergillus flavus catalyzes the degradation of uric acid to [S]-allantoin through 5-hydroxyisourate as a metastable intermediate. The second degradation step is thought either catalyzed by another specific enzyme, or spontaneous. The structure of the enzyme was known at high resolution by X-ray diffraction of I222 crystals complexed with a purine-type inhibitor (8-azaxanthin). Analyzing the X-ray structure of urate oxidase treated with an excess of urate, the natural substrate, shows unexpectedly that the active site recaptures [S]-allantoin from the racemic end product of a second degradation step.

About this Structure

2FXL is a Single protein structure of sequence from Aspergillus flavus. Full crystallographic information is available from OCA.

Reference

Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase., Gabison L, Chiadmi M, Colloc'h N, Castro B, El Hajji M, Prange T, FEBS Lett. 2006 Apr 3;580(8):2087-91. Epub 2006 Mar 10. PMID:16545381 Page seeded by OCA on Sun May 4 04:25:23 2008

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