2g0d

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[[Image:2g0d.gif|left|200px]]
[[Image:2g0d.gif|left|200px]]
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{{Structure
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|PDB= 2g0d |SIZE=350|CAPTION= <scene name='initialview01'>2g0d</scene>, resolution 2.21&Aring;
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The line below this paragraph, containing "STRUCTURE_2g0d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= nisC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1360 Lactococcus lactis subsp. lactis])
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{{STRUCTURE_2g0d| PDB=2g0d | SCENE= }}
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|RELATEDENTRY=[[2go2|2GO2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0d OCA], [http://www.ebi.ac.uk/pdbsum/2g0d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g0d RCSB]</span>
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'''Nisin cyclase'''
'''Nisin cyclase'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
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[[Category: alpha barrel]]
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[[Category: Alpha barrel]]
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[[Category: alpha toroid]]
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[[Category: Alpha toroid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:33:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:10:07 2008''
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Revision as of 01:33, 4 May 2008

Image:2g0d.gif

Template:STRUCTURE 2g0d

Nisin cyclase


Overview

Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.

About this Structure

2G0D is a Single protein structure of sequence from Lactococcus lactis subsp. lactis. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis., Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK, Science. 2006 Mar 10;311(5766):1464-7. PMID:16527981 Page seeded by OCA on Sun May 4 04:33:17 2008

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