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2g0l

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[[Image:2g0l.gif|left|200px]]
[[Image:2g0l.gif|left|200px]]
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{{Structure
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|PDB= 2g0l |SIZE=350|CAPTION= <scene name='initialview01'>2g0l</scene>
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The line below this paragraph, containing "STRUCTURE_2g0l", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene>
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|GENE= ncsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1897 Streptomyces carzinostaticus])
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|DOMAIN=
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{{STRUCTURE_2g0l| PDB=2g0l | SCENE= }}
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|RELATEDENTRY=[[1j5h|1J5H]], [[1j5i|1J5I]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0l OCA], [http://www.ebi.ac.uk/pdbsum/2g0l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g0l RCSB]</span>
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'''Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone'''
'''Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone'''
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[[Category: Stoneman, R G.]]
[[Category: Stoneman, R G.]]
[[Category: Woolfson, D N.]]
[[Category: Woolfson, D N.]]
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[[Category: beta sandwich]]
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[[Category: Beta sandwich]]
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[[Category: igg fold]]
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[[Category: Igg fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:33:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:10:12 2008''
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Revision as of 01:33, 4 May 2008

Image:2g0l.gif

Template:STRUCTURE 2g0l

Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone


Overview

Neocarzinostatin (NCS) is a 1:1 complex of an enediyne chromophore (NCSChrom), non-covalently bound to an 11 kDa protein (apoNCS). We are exploring apoNCS as a generic protein system for sequestering small molecules for therapeutic applications. Here, we disclose a new flavone ligand 1 for apoNCS and present a high-resolution NMR structure of this ligand bound to apoNCS. This is the first high-resolution structure of a completely non-cognate ligand bound to the apoNCS protein. This work provides unambiguous evidence that a completely new class of ligand can bind specifically to apoNCS. Furthermore, the mode of binding is different than that of the naphthoate-based ligands, and for such a simple hydrophobic compound, the new ligand surprisingly binds specifically. This work indicates that apo-Neocarzinostatin has multiple selective and distinct binding modes for small-molecule cargo.

About this Structure

2G0L is a Single protein structure of sequence from Streptomyces carzinostaticus. Full crystallographic information is available from OCA.

Reference

Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:16568976 Page seeded by OCA on Sun May 4 04:33:48 2008

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