User:Emily Lawson/Sandbox 1
From Proteopedia
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==Poly(A) Binding Protein (PABP)- ''Homo sapiens''== | ==Poly(A) Binding Protein (PABP)- ''Homo sapiens''== | ||
<Structure load='1CBJ' size='350' frame='true' align='right' caption='Poly (A) Binding Protein' scene='Insert optional scene name here' /> | <Structure load='1CBJ' size='350' frame='true' align='right' caption='Poly (A) Binding Protein' scene='Insert optional scene name here' /> | ||
| - | <scene name='78/781946/Pabp_linker/1'>PABP Linker</scene> | ||
| - | This is a default text for your page '''Emily Lawson/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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| + | Human Poly(A) Binding Protein (PABP) is a biopolypeptide involved in recognizing the 3'poly (A) tail of mRNA that is added to an mRNA transcript during mRNA processing.This recognition as well as PABP's interaction with other proteins and initiation factors causes it to also play a significant role in translation initiation and mRNA stabilization and degradation. PABP consists of four conserved domains of RNA recognition motifs (RRMs); however, the two N-terminal RRMs (RRM1 and RRM2) and the short linker sequence that connects them supports most of the function of PABP, so RRM3 and RRM4 may not be essential. Thus, the published X-ray structure exhibits RRM1 and RRM2 at a 2.6 Angstrom resolution. | ||
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| + | <scene name='78/781947/Biological_assembly_1/1'>biological assembly 1</scene> | ||
== Function == | == Function == | ||
===Poly (A)Binding=== | ===Poly (A)Binding=== | ||
[[Image: PABP Biological Assembly 1.jpg |100 px|left|thumb|Figure Legend ]] | [[Image: PABP Biological Assembly 1.jpg |100 px|left|thumb|Figure Legend ]] | ||
| + | <scene name='78/781946/Pabp_linker/1'>PABP Linker</scene> | ||
<scene name='78/781946/Rnp1_rnp2_primary_a_binding/1'>RNP1 and RNP2 Primary Binding Trough of Adenosine</scene> | <scene name='78/781946/Rnp1_rnp2_primary_a_binding/1'>RNP1 and RNP2 Primary Binding Trough of Adenosine</scene> | ||
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<scene name='78/781946/Adenosine_binding_wall/1'> Adenosine Binding Wall</scene> | <scene name='78/781946/Adenosine_binding_wall/1'> Adenosine Binding Wall</scene> | ||
| + | <scene name='78/781949/Lys_104_asp_105/1'>A1 and A2 interactions</scene> | ||
| + | <scene name='78/781947/Interactions_with_a3/1'>interactions with A3</scene> | ||
| + | <scene name='78/781947/Residues_interacting_with_a6/1'>interactions with A6</scene> | ||
===Translation Initiation=== | ===Translation Initiation=== | ||
<scene name='78/781946/Pabp_linker_conserved_residues/1'>PABP linker with Conserved Residues Shown</scene> | <scene name='78/781946/Pabp_linker_conserved_residues/1'>PABP linker with Conserved Residues Shown</scene> | ||
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| + | <scene name='78/781947/H1_and_h2_h2ophobic_residues/2'>Phe 74 Phe 122 Met 158 Met 161 Leu163</scene> | ||
| + | <scene name='78/781947/Hydrophilic_residues/2'>Asp70 Asp111 Asp117</scene> | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| - | + | <scene name='78/781947/Pro-ser_in_linker/1'>Pro91-Ser92</scene> | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 15:41, 27 March 2018
Contents |
Poly(A) Binding Protein (PABP)- Homo sapiens
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Human Poly(A) Binding Protein (PABP) is a biopolypeptide involved in recognizing the 3'poly (A) tail of mRNA that is added to an mRNA transcript during mRNA processing.This recognition as well as PABP's interaction with other proteins and initiation factors causes it to also play a significant role in translation initiation and mRNA stabilization and degradation. PABP consists of four conserved domains of RNA recognition motifs (RRMs); however, the two N-terminal RRMs (RRM1 and RRM2) and the short linker sequence that connects them supports most of the function of PABP, so RRM3 and RRM4 may not be essential. Thus, the published X-ray structure exhibits RRM1 and RRM2 at a 2.6 Angstrom resolution.
Function
Poly (A)Binding
Translation Initiation
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
