2g1m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2g1m.gif|left|200px]]
[[Image:2g1m.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2g1m |SIZE=350|CAPTION= <scene name='initialview01'>2g1m</scene>, resolution 2.20&Aring;
+
The line below this paragraph, containing "STRUCTURE_2g1m", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=4HG:N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE'>4HG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= EGLN1, C1orf12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2g1m| PDB=2g1m | SCENE= }}
-
|RELATEDENTRY=[[2g19|2G19]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g1m OCA], [http://www.ebi.ac.uk/pdbsum/2g1m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g1m RCSB]</span>
+
-
}}
+
'''Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)'''
'''Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)'''
Line 28: Line 25:
[[Category: Schofield, C J.]]
[[Category: Schofield, C J.]]
[[Category: 2-oxoglutarate]]
[[Category: 2-oxoglutarate]]
-
[[Category: dsbh]]
+
[[Category: Dsbh]]
-
[[Category: elgn]]
+
[[Category: Elgn]]
-
[[Category: hif]]
+
[[Category: Hif]]
-
[[Category: hph]]
+
[[Category: Hph]]
-
[[Category: hydroxylase]]
+
[[Category: Hydroxylase]]
-
[[Category: hypoxia]]
+
[[Category: Hypoxia]]
-
[[Category: inhibitor]]
+
[[Category: Inhibitor]]
-
[[Category: oxygenase]]
+
[[Category: Oxygenase]]
-
[[Category: phd2]]
+
[[Category: Phd2]]
-
[[Category: prolyl hydroxylase]]
+
[[Category: Prolyl hydroxylase]]
-
[[Category: sm-20]]
+
[[Category: Sm-20]]
-
[[Category: transcription]]
+
[[Category: Transcription]]
-
[[Category: transcription activator]]
+
[[Category: Transcription activator]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:35:42 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:10:36 2008''
+

Revision as of 01:35, 4 May 2008

Image:2g1m.gif

Template:STRUCTURE 2g1m

Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)


Overview

Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-alpha subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to chronic hypoxia; the PHDs thus act as an oxygen-sensing component of the HIF system, and their inhibition mimics the hypoxic response. We describe crystal structures of the catalytic domain of human PHD2, an important prolyl-4-hydroxylase in the human hypoxic response in normal cells, in complex with Fe(II) and an inhibitor to 1.7 A resolution. PHD2 crystallizes as a homotrimer and contains a double-stranded beta-helix core fold common to the Fe(II) and 2-oxoglutarate-dependant dioxygenase family, the residues of which are well conserved in the three human PHD enzymes (PHD 1-3). The structure provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.

About this Structure

2G1M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)., McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Lienard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ, Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16. PMID:16782814 Page seeded by OCA on Sun May 4 04:35:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2g1m"
Personal tools