5ud8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Mutant Ig-like Domain== | |
| - | + | <StructureSection load='5ud8' size='340' side='right' caption='[[5ud8]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ud8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UD8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ud7|5ud7]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ud8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ud8 OCA], [http://pdbe.org/5ud8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ud8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ud8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ud8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] Progressive non-fluent aphasia;Amyotrophic lateral sclerosis;Nasu-Hakola disease;Semantic dementia;Behavioral variant of frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TREM2_HUMAN TREM2_HUMAN]] May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.<ref>PMID:10799849</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Min, X]] | [[Category: Min, X]] | ||
[[Category: Sudom, A]] | [[Category: Sudom, A]] | ||
[[Category: Wang, Z]] | [[Category: Wang, Z]] | ||
| + | [[Category: Ig-like domain]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 05:52, 4 April 2018
Crystal Structure of Mutant Ig-like Domain
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