6cb8

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'''Unreleased structure'''
 
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The entry 6cb8 is ON HOLD until Paper Publication
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==Cryo-EM structure of the Gasdermin A3 membrane pore==
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<StructureSection load='6cb8' size='340' side='right' caption='[[6cb8]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6cb8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CB8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cb8 OCA], [http://pdbe.org/6cb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cb8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cb8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE]] Defects in Gsdma3 are the cause of a number of alopecia phenotypes, bareskin (Bsk), defolliculated (Dfl), finnegan (Fgn) reduced coat 2 (Rco2), Rex-denuded (Re-den) and recombination induced mutation 3 (Rim3). These are dominant conditions characterized by loss of hair.<ref>PMID:15475261</ref> <ref>PMID:15737203</ref> <ref>PMID:17572385</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE]] Upon activation, mediates pyroptosis (PubMed:26375003). May play a role in the transition from catagen to telogen at the end of hair follicle morphogenesis (PubMed:15475261).<ref>PMID:15475261</ref> <ref>PMID:26375003</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ruan, J]]
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[[Category: Wu, H]]
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[[Category: Immune system]]
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[[Category: Pore forming protein]]
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[[Category: Pyroptosis]]

Revision as of 05:34, 25 April 2018

Cryo-EM structure of the Gasdermin A3 membrane pore

6cb8, resolution 3.80Å

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