6fwz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with UDP-GlcNAc== | |
| - | + | <StructureSection load='6fwz' size='340' side='right' caption='[[6fwz]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6fwz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FWZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine--dolichyl-phosphate_N-acetylglucosaminephosphotransferase UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.15 2.7.8.15] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fwz OCA], [http://pdbe.org/6fwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fwz RCSB], [http://www.ebi.ac.uk/pdbsum/6fwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fwz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] DPAGT1-CDG;Congenital myasthenic syndromes with glycosylation defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Beeson, D]] | ||
| + | [[Category: Belaya, K]] | ||
| + | [[Category: Berridge, G]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Carpenter, E P]] | ||
| + | [[Category: Chalk, R]] | ||
| + | [[Category: Chu, A]] | ||
| + | [[Category: Dong, L]] | ||
| + | [[Category: Dong, Y Y]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Goubin, S]] | ||
| + | [[Category: Kupinska, K]] | ||
| + | [[Category: Mahajan, P]] | ||
| + | [[Category: Mukhopadhyay, S]] | ||
| + | [[Category: Pike, A C.W]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tessitore, A]] | ||
| + | [[Category: Wang, D]] | ||
| + | [[Category: Antibiotic]] | ||
| + | [[Category: Congenital myasthenic syndrome]] | ||
| + | [[Category: Integral membrane protein]] | ||
| + | [[Category: Pnpt]] | ||
| + | [[Category: Protein glycosylation]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:23, 25 July 2018
Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with UDP-GlcNAc
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Categories: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | Arrowsmith, C H | Beeson, D | Belaya, K | Berridge, G | Bountra, C | Burgess-Brown, N | Carpenter, E P | Chalk, R | Chu, A | Dong, L | Dong, Y Y | Edwards, A M | Goubin, S | Kupinska, K | Mahajan, P | Mukhopadhyay, S | Pike, A C.W | Structural genomic | Tessitore, A | Wang, D | Antibiotic | Congenital myasthenic syndrome | Integral membrane protein | Pnpt | Protein glycosylation | Sgc | Transferase
