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6g0p

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'''Unreleased structure'''
 
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The entry 6g0p is ON HOLD
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==Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)==
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<StructureSection load='6g0p' size='340' side='right' caption='[[6g0p]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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Authors: Filippakopoulos, P., Picaud, S., Krojer, T., Sorrell, F., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6g0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0P FirstGlance]. <br>
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Description: Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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[[Category: Pike, A.C.W]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0p OCA], [http://pdbe.org/6g0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0p RCSB], [http://www.ebi.ac.uk/pdbsum/6g0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0p ProSAT]</span></td></tr>
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[[Category: Von Delft, F]]
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</table>
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[[Category: Picaud, S]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). [[http://www.uniprot.org/uniprot/E2F1_HUMAN E2F1_HUMAN]] Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.<ref>PMID:8170954</ref> <ref>PMID:10675335</ref> <ref>PMID:12717439</ref> <ref>PMID:17704056</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
[[Category: Filippakopoulos, P]]
[[Category: Filippakopoulos, P]]
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[[Category: Edwards, A.M]]
 
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Bountra, C]]
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[[Category: Picaud, S]]
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[[Category: Pike, A C.W]]
[[Category: Sorrell, F]]
[[Category: Sorrell, F]]
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[[Category: Bromodomain]]
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[[Category: Complex]]
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[[Category: Transcription]]

Revision as of 20:30, 2 December 2018

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)

6g0p, resolution 1.30Å

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