2g5q
From Proteopedia
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'''Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.''' | '''Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G5Q OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group., Kondo J, Francois B, Russell RJ, Murray JB, Westhof E, Biochimie. 2006 Aug;88(8):1027-31. Epub 2006 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16806634 16806634] | Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group., Kondo J, Francois B, Russell RJ, Murray JB, Westhof E, Biochimie. 2006 Aug;88(8):1027-31. Epub 2006 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16806634 16806634] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Francois, B.]] | [[Category: Francois, B.]] | ||
[[Category: Kondo, J.]] | [[Category: Kondo, J.]] | ||
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[[Category: Russell, R J.M.]] | [[Category: Russell, R J.M.]] | ||
[[Category: Westhof, E.]] | [[Category: Westhof, E.]] | ||
| - | [[Category: | + | [[Category: Amikacin]] |
| - | [[Category: | + | [[Category: Aminoglycoside]] |
| - | [[Category: | + | [[Category: Haba group]] |
| - | [[Category: | + | [[Category: Ribosomal decoding site]] |
| - | [[Category: | + | [[Category: Rna]] |
| - | [[Category: | + | [[Category: X-ray analysis]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:43:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:43, 4 May 2008
Crystal structures of the bacterial ribosomal decoding site complexed with amikacin.
Overview
Amikacin is the 4,6-linked aminoglycoside modified at position N1 of the 2-deoxystreptamine ring (ring II) by the L-haba group. In the present study, the crystal structure of a complex between oligonucleotide containing the bacterial ribosomal A site and amikacin has been solved at 2.7 A resolution. Amikacin specifically binds to the A site in practically the same way as its parent compound kanamycin. In addition, the L-haba group interacts with the upper side of the A site through two direct contacts, O2*...H-N4(C1496) and N4*-H...O6(G1497). The present crystal structure shows how the introduction of the L-haba group on ring II of aminoglycoside is an effective mutation for obtaining a higher affinity to the bacterial A site.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group., Kondo J, Francois B, Russell RJ, Murray JB, Westhof E, Biochimie. 2006 Aug;88(8):1027-31. Epub 2006 Jun 13. PMID:16806634 Page seeded by OCA on Sun May 4 04:43:06 2008
