2g5b

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[[Image:2g5b.gif|left|200px]]
[[Image:2g5b.gif|left|200px]]
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{{Structure
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|PDB= 2g5b |SIZE=350|CAPTION= <scene name='initialview01'>2g5b</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2g5b", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2g5b| PDB=2g5b | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g5b OCA], [http://www.ebi.ac.uk/pdbsum/2g5b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g5b RCSB]</span>
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'''Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide.'''
'''Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide.'''
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[[Category: Peyerl, F W.]]
[[Category: Peyerl, F W.]]
[[Category: 6a7]]
[[Category: 6a7]]
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[[Category: antibody]]
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[[Category: Antibody]]
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[[Category: bax]]
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[[Category: Bax]]
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[[Category: fab]]
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[[Category: Fab]]
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[[Category: fab-peptide complex]]
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[[Category: Fab-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:42:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:07 2008''
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Revision as of 01:42, 4 May 2008

Image:2g5b.gif

Template:STRUCTURE 2g5b

Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide.


Overview

The Bcl-2 family member Bax plays a critical role in apoptosis. In healthy resting cells, Bax resides in the cytoplasm and loosely attached to the mitochondrial membrane. Apoptotic stimuli induce Bax activation, which is characterized by translocation and multimerization on the mitochondrial membrane surface resulting in exposure of an amino terminal epitope recognized by the monoclonal antibody 6A7. To understand the structural changes that occur during Bax activation, we determined the crystal structure of a Bax peptide bound to the 6A7 Fab fragment to a resolution of 2.3 A. The structure reveals the conformation of the 6A7 peptide epitope on Bax in the activated form and elucidates the extensive structural changes that Bax must undergo during the conversion from its native to its activated conformation.

About this Structure

2G5B is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex., Peyerl FW, Dai S, Murphy GA, Crawford F, White J, Marrack P, Kappler JW, Cell Death Differ. 2007 Mar;14(3):447-52. Epub 2006 Sep 1. PMID:16946732 Page seeded by OCA on Sun May 4 04:42:08 2008

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