1ul9

From Proteopedia

(Difference between revisions)

Revision as of 07:29, 30 December 2020

CGL2 ligandfree

Structural highlights

1ul9 is a 2 chain structure with sequence from Copci. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1sla, 1qmj, 1gan, 1c1f, 1bkz, 1a3k, 1lcl, 1is5, 1ulc, 1uld, 1ule, 1ulf, 1ulg
Gene:	cgl2 (COPCI)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.

Structure and functional analysis of the fungal galectin CGL2.,Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N Structure. 2004 Apr;12(4):689-702. PMID:15062091^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cooper DN, Boulianne RP, Charlton S, Farrell EM, Sucher A, Lu BC. Fungal galectins, sequence and specificity of two isolectins from Coprinus cinereus. J Biol Chem. 1997 Jan 17;272(3):1514-21. PMID:8999822
↑ Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N. Structure and functional analysis of the fungal galectin CGL2. Structure. 2004 Apr;12(4):689-702. PMID:15062091 doi:10.1016/j.str.2004.03.002

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ul9"

@@ Line 1: / Line 1: @@
 ==CGL2 ligandfree==
-<StructureSection load='1ul9' size='340' side='right' caption='[[1ul9]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
+<StructureSection load='1ul9' size='340' side='right'caption='[[1ul9]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ul9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Copci Copci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UL9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ul9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Copci Copci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UL9 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sla|1sla]], [[1qmj|1qmj]], [[1gan|1gan]], [[1c1f|1c1f]], [[1bkz|1bkz]], [[1a3k|1a3k]], [[1lcl|1lcl]], [[1is5|1is5]], [[1ulc|1ulc]], [[1uld|1uld]], [[1ule|1ule]], [[1ulf|1ulf]], [[1ulg|1ulg]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sla|1sla]], [[1qmj|1qmj]], [[1gan|1gan]], [[1c1f|1c1f]], [[1bkz|1bkz]], [[1a3k|1a3k]], [[1lcl|1lcl]], [[1is5|1is5]], [[1ulc|1ulc]], [[1uld|1uld]], [[1ule|1ule]], [[1ulf|1ulf]], [[1ulg|1ulg]]</div></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cgl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5346 COPCI])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ul9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul9 OCA], [http://pdbe.org/1ul9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ul9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ul9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ul9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul9 OCA], [http://pdbe.org/1ul9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ul9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ul9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul9 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 31: / Line 31: @@
 ==See Also==
-*[[Galectin|Galectin]]
+*[[Galectin 3D structures|Galectin 3D structures]]
 == References ==
 <references/>
@@ Line 37: / Line 37: @@
 </StructureSection>
 [[Category: Copci]]
+[[Category: Large Structures]]
 [[Category: Aebi, M]]
 [[Category: Ban, N]]

1ul9

From Proteopedia

Revision as of 07:29, 30 December 2020

CGL2 ligandfree

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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