2g9c
From Proteopedia
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[[Image:2g9c.gif|left|200px]] | [[Image:2g9c.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_2g9c| PDB=2g9c | SCENE= }} | |
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'''Modified pyrimidines Specifically bind the purine riboswitch''' | '''Modified pyrimidines Specifically bind the purine riboswitch''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. | |
==Reference== | ==Reference== | ||
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468] | Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Batey, R T.]] | [[Category: Batey, R T.]] | ||
[[Category: Gilbert, S D.]] | [[Category: Gilbert, S D.]] | ||
[[Category: Mediatore, S J.]] | [[Category: Mediatore, S J.]] | ||
| - | [[Category: | + | [[Category: Mrna]] |
| - | [[Category: | + | [[Category: Riboswitch]] |
| - | [[Category: | + | [[Category: Rna-ligand complex]] |
| - | [[Category: | + | [[Category: Triaminopyrimidine]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:50:43 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:50, 4 May 2008
Modified pyrimidines Specifically bind the purine riboswitch
Overview
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
About this Structure
Full crystallographic information is available from OCA.
Reference
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468 Page seeded by OCA on Sun May 4 04:50:43 2008
