2ga8

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[[Image:2ga8.jpg|left|200px]]
[[Image:2ga8.jpg|left|200px]]
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{{Structure
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|PDB= 2ga8 |SIZE=350|CAPTION= <scene name='initialview01'>2ga8</scene>, resolution 1.775&Aring;
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The line below this paragraph, containing "STRUCTURE_2ga8", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK09270 frcK], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1072 CoaA]</span>
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{{STRUCTURE_2ga8| PDB=2ga8 | SCENE= }}
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|RELATEDENTRY=[[1uj2|1UJ2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ga8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ga8 OCA], [http://www.ebi.ac.uk/pdbsum/2ga8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ga8 RCSB]</span>
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'''Crystal structure of YFH7 from Saccharomyces cerevisiae: a putative P-loop containing kinase with a circular permutation.'''
'''Crystal structure of YFH7 from Saccharomyces cerevisiae: a putative P-loop containing kinase with a circular permutation.'''
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[[Category: Chaptal, V.]]
[[Category: Chaptal, V.]]
[[Category: Morera, S.]]
[[Category: Morera, S.]]
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[[Category: unknown function]]
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[[Category: Unknown function]]
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[[Category: yfh7]]
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[[Category: Yfh7]]
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[[Category: yfr007w]]
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[[Category: Yfr007w]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:52:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:55 2008''
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Revision as of 01:52, 4 May 2008

Image:2ga8.jpg

Template:STRUCTURE 2ga8

Crystal structure of YFH7 from Saccharomyces cerevisiae: a putative P-loop containing kinase with a circular permutation.


Overview

Genome sequencing projects have revealed that P-loop proteins are highly represented in all organisms and that many of them have no attributed function. They are characterized by a conserved nucleotide-binding domain and carry different activities implicated in many cellular processes. Saccharomyces cerevisiae YFH7 is one of these P-loop proteins of unknown function. In this work we tried to integrate bioinformatics, structure, and enzymology to discover the function of YFH7. Sequence analysis revealed that yeast YFH7 is a yeast-specific protein showing weak similarity with the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop containing kinases. A large insertion of about 100 residues distinguishes YFH7 from other members of the family. The 1.95 A resolution crystal structure of YFH7 solved using the SAD method confirmed that YFH7 has a fold similar to the PRK/URK/PANK family, with the characteristic core, lid, and NMP(bind) domains. An additional alpha/beta domain of novel topology corresponds to the large sequence insertion. Structural and ligand binding analysis combined with enzymatic assays suggest that YFH7 is an ATP-dependent small molecule kinase with new substrate specificity. Proteins 2007. (c) 2007 Wiley-Liss, Inc.

About this Structure

2GA8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis identify the P-loop containing protein YFH7 of Saccharomyces cerevisiae as an ATP-dependent kinase., Gueguen-Chaignon V, Chaptal V, Lariviere L, Costa N, Lopes P, Morera S, Nessler S, Proteins. 2007 Nov 14;. PMID:18004758 Page seeded by OCA on Sun May 4 04:52:45 2008

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