Botulinum neurotoxin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | CBP contains a <scene name='67/671726/Cv/ | + | CBP contains a <scene name='67/671726/Cv/9'>light or catalytic domain</scene> (LC, residues 1-440, in magenta) and a <scene name='67/671726/Cv/10'>heavy</scene> (HC, residues 441-1296, in cyan) chain. CBP HC contains two modules: |
| - | the N-terminal <scene name='67/671726/Cv/ | + | the N-terminal <scene name='67/671726/Cv/11'>translocation domain</scene> (residues 441-875, in salmon) and the C-terminal <scene name='67/671726/Cv/12'>receptor-binding domain</scene> (residues 876-1296, in yellow). <scene name='67/671726/Cv/13'>Cofactor Zn+2 coordination site</scene>. <ref>PMID:9783750</ref> |
</StructureSection> | </StructureSection> | ||
Revision as of 13:57, 24 May 2018
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3D structures of botulinum neurotoxin
Updated on 24-May-2018
References
- ↑ Montecucco C, Molgo J. Botulinal neurotoxins: revival of an old killer. Curr Opin Pharmacol. 2005 Jun;5(3):274-9. PMID:15907915 doi:http://dx.doi.org/10.1016/j.coph.2004.12.006
- ↑ Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:9783750 doi:10.1038/2338
