2gdc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2gdc.gif|left|200px]]
[[Image:2gdc.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2gdc |SIZE=350|CAPTION= <scene name='initialview01'>2gdc</scene>, resolution 2.74&Aring;
+
The line below this paragraph, containing "STRUCTURE_2gdc", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= VCL, VINC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]), ipaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella flexneri])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2gdc| PDB=2gdc | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdc OCA], [http://www.ebi.ac.uk/pdbsum/2gdc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gdc RCSB]</span>
+
-
}}
+
'''Structure of Vinculin VD1 / IpaA560-633 complex'''
'''Structure of Vinculin VD1 / IpaA560-633 complex'''
Line 31: Line 28:
[[Category: Hamiaux, C.]]
[[Category: Hamiaux, C.]]
[[Category: Parsot, C.]]
[[Category: Parsot, C.]]
-
[[Category: helical bundle conversion]]
+
[[Category: Helical bundle conversion]]
-
[[Category: ipaa/vinculin complex]]
+
[[Category: Ipaa/vinculin complex]]
-
[[Category: shigella flexneri]]
+
[[Category: Shigella flexneri]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:58:33 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:15:09 2008''
+

Revision as of 01:58, 4 May 2008

Image:2gdc.gif

Template:STRUCTURE 2gdc

Structure of Vinculin VD1 / IpaA560-633 complex


Overview

Invasion of epithelial cells by Shigella flexneri is characterized by cytoskeletal rearrangements of the host cell membrane, promoting internalization of the bacterium. The bacterial effector IpaA is injected into the epithelial cell by a type III secretion apparatus and recruits vinculin to regulate actin polymerization at the site of entry. We analysed the complex formed between a carboxy-terminal fragment of IpaA (IpaA(560-633)) and the vinculin D1 domain (VD1), both in crystals and in solution. We present evidence that IpaA(560-633) has two alpha-helical vinculin-binding sites that simultaneously bind two VD1 molecules. The interaction of IpaA(560-633) with VD1 is highly similar to the interaction of the endogenous, eukaryotic proteins talin and alpha-actinin with VD1, showing that Shigella uses a structural mimicry strategy to activate vinculin.

About this Structure

2GDC is a Protein complex structure of sequences from Gallus gallus and Shigella flexneri. Full crystallographic information is available from OCA.

Reference

Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri., Hamiaux C, van Eerde A, Parsot C, Broos J, Dijkstra BW, EMBO Rep. 2006 Aug;7(8):794-9. Epub 2006 Jul 7. PMID:16826238 Page seeded by OCA on Sun May 4 04:58:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gdc"
Personal tools